The Haemophilus somnus sequencing project is a collaboration between Dr.
Thomas Inzana, Ph.D. at Virginia
Polytechnic Institute and State University and Dr. David Dyer,
Ph.D. of the Laboratory for Genomics and Bioinformatics.
The H. somnus strain 2336 selected for sequencing, which was isolated from a calf with
pneumonia and was provided by Dr. Lynette Corbeil, is host specific for
bovines and possibly ovines, and is responsible for a wide variety of
systemic diseases. This project is funded by USDA/CSREES grant #2001-52100-11314.
Download contigs from the finished Haemophilus somnus assembly
BLAST against Haemophilus somnus contigs
Sequal - Generate a graph of Phrap quality vs. base position.
Charolais bull with thrombotic meningoencephalitis (TME). This multi-systemic disease
is more common in animals in feedlots, and is characterized by sudden
onset and marked pyrexia. Affected animals may be severely depressed
with salivation, drooping ears and eyelids. Death may follow in a
Figure 3. Pneumonia may occur in the absence of other clinical diseases or in conjunction
with TME. H. somnus may cause pneumonia as a single entity or in combination
with Pasteurella bacteria (shipping fever). The lungs of this animal
demonstrate suppurative bronchopneumonia with severe cranioventral
hemorrhage and consolidation.
Figure 4. Postmortem view of the brain of a bovine with TME. Note congestion of the
gray matter, with cerebral hemorrhages, and meningitis.
Figure 1. Electron micrograph of Haemophilus somnus, a gram-negative coccobacillus
of the family Pasteurellaceae. Although H. somnus does not form a true
capsule, under particular growth conditions it does shed an exopolysaccharide